Isoform-level microRNA-155 target prediction using RNA-seq

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Isoform-level microRNA-155 target prediction using RNA-seq

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MOTIVATION RNA-sequencing technologies provide a powerful tool for expression analysis at gene and isoform level, but accurate estimation of isoform abundance is still a challenge. Standard assumption of uniform read intensity would yield biased estimates when the read intensity is in fact non-uniform. The problem is that, without strong assumptions, the read intensity pattern is not identifiab...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2011

ISSN: 1362-4962,0305-1048

DOI: 10.1093/nar/gkr042